Top stories today:

1. Microsoft, OpenAI said to clash over definition of AGI
2. Google’s AlphaGenome predicts how DNA changes affect function
3. Kalshi raises $185M at $2B valuation in round led by Paradigm
4. Meta said to have poached 3 OpenAI researchers
5. NVIDIA shares hit all-time high to reclaim world’s largest stock record

0. Data and calendar

Listen to our AI-generated podcast summarizing today’s newsletter (beware of hallucinations):

1. Microsoft, OpenAI said to clash over definition of AGI

• OpenAI and Microsoft are renegotiating their deal as OpenAI seeks to convert into a for-profit.

• Tensions have spiked as both sides reportedly threatened drastic action in the past 2 weeks.

• OpenAI can limit Microsoft’s access at the AGI milestone, a clause Microsoft is now contesting.

• AGI could soon be declared, OpenAI execs have reportedly hinted over the past 8 months.

• Microsoft is reportedly aiming to scrap the AGI clause or secure exclusive OpenAI IP access in talks.

3. Google DeepMind’s AlphaGenome uses AI to predict how DNA changes affect function

Google claims slight improvements against current best methods:

• Predicts how DNA changes impact gene activity and health.

• Key features include long sequence-context at high resolution, multimodal prediction, and splice-junction modeling.

• Trained on data from public consortia like ENCODE, GTEx, 4D Nucleome, and FANTOM5.

• Not designed for “personal genome prediction, a known challenge for AI models,” Google said.

• Available for non-commercial use via AlphaGenome API.

4. Kalshi raises $185M at $2B valuation in round led by Paradigm