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Eli Lilly strikes $2.75B deal with Insilico for AI-developed drugs

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Top stories today:

  1. Eli Lilly strikes $2.75B deal with Insilico for AI-developed drugs
  2. Meta to unveil Ray-Ban smart glasses for prescription wearers this week
  3. xAI loses last cofounder Ross Nordeen, ending Elon’s founding team
  4. Physical Intelligence said to seek $1B round at $11B+ valuation
  5. Kalshi secures margin trading license to attract institutional investors
  6. Meta’s Avocado seen testing multiple AI variants, including 9B model

0. Data and calendar

All values as of 6 AM ET / 3 AM PT, other than S&P500 and NASDAQ close (4 PM ET / 1 PM PT).

All times are ET.

Listen to our AI-generated podcast summarizing today’s newsletter (beware of hallucinations):

1. Eli Lilly strikes $2.75B deal with Insilico for AI-developed drugs

Insilico Medicine shares closed +3% Mon. after rising as much as 15%, their strongest intraday rally in ~2 months:

  • Insilico will receive $15M upfront, with the rest tied to regulatory and commercial milestones.

  • The deal also includes royalties on future sales.

  • Insilico has developed at least 28 drugs using GenAI, ~50% of them are already in clinical stages, CEO Alex Zhavoronkov said.

  • 2023: Eli Lilly and Insilico signed an AI software licensing deal.

  • Insilico develops AI outside China but conducts early preclinical work there.

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3. Meta said to launch Ray-Ban smart glasses for prescription wearers this week

  • Rectangular and rounded styles are expected.

  • Codenamed Scriber and Blazer, they are not next-gen Meta smart glasses.

  • “[B]illions of people wear glasses or contacts,” Mark Zuckerberg said, hinting at a broader push into prescription wearers.

4. xAI loses last cofounder Ross Nordeen, ending Elon’s founding team

Nordeen has also lost the badge on X that identifies him as an xAI employee:

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